Alternatives to DeSmuME
Long-running Nintendo DS emulator with high-resolution rendering. The listings below can replace it for an important use case. Each note says what changes if you switch.
The original
DeSmuME
Long-running Nintendo DS emulator with high-resolution rendering.
Replacements
Listings that take over the same core job as DeSmuME.
melonDS
A Nintendo DS and DSi emulator focused on accuracy and speed, with local wireless between emulated consoles.
melonDS is faster and more accurate for many DS games, adds DSi emulation and local wireless between instances, but needs BIOS and firmware dumps and lacks internet netplay.
NooDS
A fast, portable open-source emulator for the Nintendo DS and Game Boy Advance.
NooDS emulates both DS and GBA with multi-core software rendering and upscaling, adds Android and homebrew console builds, but has a smaller feature set and one main developer.
SkyEmu
A low-level emulator for the Game Boy, Game Boy Color, Game Boy Advance and Nintendo DS.
SkyEmu covers Game Boy, Game Boy Color, GBA and DS in one low-level emulator, but lists only macOS and Linux and lacks DeSmuME's cheat database and movie tools.
Also worth comparing
These listings name DeSmuME as their own alternative, so the relationship runs both ways.
no$gba
A Game Boy Advance, Nintendo DS and DSi emulator with a source-level debugger.
DeSmuME is an open-source GPL-2.0 Nintendo DS emulator on three desktop systems with high-resolution rendering and movie recording, but it has infrequent releases and no GBA support.
Similar software
Related functionality, not a direct replacement.
Azahar
Run Nintendo 3DS software with an open-source emulator.
mGBA
A Game Boy Advance emulator that gets the accuracy right and still runs at full speed on weak hardware.
BizHawk
A multi-system emulator built for tool-assisted speedrunning, with rewinding, frame stepping, memory search and input recording.
Dolphin
The GameCube and Wii emulator, running those games at higher resolutions than the consoles ever managed.
PPSSPP
A PSP emulator that needs no BIOS file and runs handheld games in HD on phones and PCs.